Институт органического синтеза им. И.Я. Постовского Уральского отделения Российской академии наук Events Ads Media Site map Search
Home Official Information About Structure Common structure Administration Laboratory of Heterocyclic Compounds Laboratory of Organofluorine Compounds Laboratory of Asymmetric Synthesis Laboratory of Organic Materials Laboratory of Coordination Compounds Laboratory of Medical Chemistry Labpratory of Perspective Organic Materials Laboratory of NMR and IR Spectroscopy LCMS Group XRD Group Elemental Analysis Group Financial and Economic Department Technological Laboratory Support Staff Details Science and universities Vacancies Hall of Fame Counter-Terrorist instructions Antimonopoly Committee Labor Protection Documents Director Elections Purchases Achievements Awards Elaborations Triazavirin Lysomustine Levofloxacin Silativit Science General Information Academic Board Dissertations Monographs Publications Reports Major scientific project Postgraduate Courses General Information Admission Committee / Information Postgraduate Courses / Information Structure Documents Education Education Standarts Management. Teaching personel Material and technical support Grants Paid educational services Financial and economic activity Vacancies Schedules Plans and Work Programmes Joint-Use Center Common information Equipment Procedures Plan List of services Make an order Council of young scientists Public Activity Mass Media about IOS Conferences XX Mendeleev Congress on General and Applied Chemistry Conference site Photo report 4th Russian Conference on Medicinal Chemistry with international participants VI Международная конференция «Современные синтетические методологии для создания лекарственных препаратов и функциональных материалов» Contacts Anti-corruption Trade Union Утверждена программа «Развитие новых методов и технологий органического синтеза» на 2019-2023 гг. Презентация на Иннопроме-2019 Сведения о результатах деятельности для экспертной оценки ИОС УрО РАН за период с 2014 года по 2018 год	Laboratory of Heterocyclic Compounds Head of the Laboratory Charushin Valeriy Nikolaevich Phone: +7 (343) 3741189 E-mail: charushin @ ios.uran.ru (адрес набирать без пробелов / no spaces in E-mail) send a letter Scientific Supervisor Chupakhin Oleg Nikolaevich Phone: +7 (343) 3741189 Электронная почта: chupakhin @ ios.uran.ru (адрес набирать без пробелов) send a letter Main research trends Development of synthesis, functionalization and transformation methods for six-membered nitrogen-containing heterocycles, heterocycle-containing macrocyclic compounds to create biologically active substances and new materials for technical applications. Study of the special processes in azines, forced by nucleophilic attack on unsubstituted carbon atom. The research of substitution reaction of nontraditional leaving groups in azines, i.e. hydrogen atom or heterocycles. Development of synthetic methods for heterocyclic compounds by means of multi-component reactions. Synthesis of molecular receptors.

Most important results:

New original methods for synthesis of functionalized azoloannulated pyridines, pyrimidines, 1,2,4-triazines were developed based on nucleophilic addition, nucleophilic substitution of hydrogen and cine-substitution reactions.


(Rusinov G.L., Plekhanov P.V., Rusinov V.L., Chupakhin O.N., Aleksandov G.G., Russ. J. Org. Chem., 1998, 290.
Rusinov G.L., Beresnev D.G., Chupakhin O.N., Russ. J. Org. Chem., 1998, 450.
Rusinov G.L., Mikhailov V.L., Chupakhin O.N., Russ. Chem. Bull., 1999, 1391.
Rusinov G.L., Plekhanov P.V., Ponomareva A.U., Chupakhin O.N., Mendeleev Comm., 1999, p. 233.
Rusinov G.L., Slepukhin P.A., Charushin V.N., Chupakhin O.N., Mendeleev Comm., 2001, p. 78.
Rusinov G.L., Itsikson N.A., Beresnev D.G., Kodess M.I., Chupakhin O.N., Russ. Chem. Bull., 2001, p.2183
Rusinov G.L., Itsikson N.A., Beresnev D.G., Koryakova O.V., Chupakhin O.N., Heterocycl. Comm., 2002, pp. 75-78.)

A new methodology for formation of condensed heterocycles using tandem reactions AN-AN, AN-SNipso, SNH-SNipso was developed.
For example:

(Bartashevich E.V, Plekhanov P.V., Rusinov G.L., Potemkin V.A., Belik A.V., Chupakhin O.N., Russ. Chem. Bull., 1999, p.1391. Beresnev D.G., Rusinov G.L., Chupakhin O.N., Nounhoeffer H., Mendeleev Comm., 2000, pp. 58-59.
Chupakhin O.N., Rusinov G.L., Beresnev D.G., Charushin V.N. and Neunhoeffer H., J. Heterocycl. Chem., 2001, pp. 901-907.)

[4+2]Cycloaddition and heterocycle substitution reactions in the series of 1,2,4,5-tetrazine were studied. New synthetic routes to pyridazine and s-tetrazine derivatives not available by other synthetic procedures were elaborated.

(Latosh N.I., Rusinov G.L., Ganebnykh I.N., Chupakhin O.N., Russ. J. Org. Chem., 1999, Vol. 35, N9, pp. 1363-1371.
Rusinov G.L., Ganebnykh I.N., Chupakhin O.N., Russ. J. Org. Chem., 1999, Vol.35, N9, pp. 1350-1354.
Rusinov G.L., Ishmetova R.I., Latosh N.I., Ganebnykh I.N., Chupakhin O.N., Potemkin V.A., Russ. Chem. Bull., 2000, Vol. 49, N2, pp. 355-362.
Rusinov G.L., Ishmetova R.I., Ganebnykh I.N., Chupakhin O.N., Aleksandrov G.G., Litvinov I.A., Heterocycl. Commun., 2003, Vol.9, N1, p . 39-44.)

Based on direct bond formation between macrocyclic compound and unsubstituted carbon atom of heterocycle a novel method for introducing heterocyclic moieties to macrocyclic compounds (crown-ethers, calixarenes, calixhetarenes) was found.
For example:

Chupakhin O.N., Rusinov G.L., Beresnev D.G., Itsikson N.A., Russ. J. Org. Chem., 1999, p.1278.
Rusinov G.L., Beresnev D.G., Itsikson N.A., Chupakhin O.N., Heterocycles, 2001, pp. 2349-2359.
Rusinov G.L., Itsikson N.A., Beresnev D.G., Koryakova O.V., Chupakhin O.N.,Heterocycl. Comm., 2002, pp. 75-78.

Pre-clinical trials of a new antituberculous agent IOS-41 was successfully performed. The compound is more effective than most of known modern Russian and foreign antituberculous analogs.

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